Lab meeting schedule 2025
Meetings for Spring 2025 is scheduled at Monday 13:30PM in PH 19-201 conference room. We will have 1 or 2 presenters at each meeting. We strongly prefer the chalk talk format without too much specific presentations especially on the background knowledge and methodology. Figures are encouraged to better communicate results and discoveries and will be shown on the screen.
We will not have hybrid zoom meeting unless external collaborators / presenters are involved.
- Jan 13, Kick-off meeting
- Jan 20, No meeting (MLK Day)
- Jan 27, Ru, SSU and SSU QTL (I)
- Feb 3, Yifei, transBoost (I)
- Feb 10, Xuewei, Anjing and Haochen, orthogonal data validation approaches
- Feb 17, No meeting (President Day)
- Feb 24, Ruixi, Multiome data for African brains and QTL analysis (I)
- March 3 Haochen and Alex, fine-mapping methods project updates
- March 10, Ru and Gao, current status of xQTL manuscript bundle
- March 17, Anjing, multifSuSiE on multiome data
- March 24, Ru, SSU and SSU QTL (II)
- March 31, Chunming, AD TWAS updates
- April 7, Guest speaker, glycoQTL and Guest speaker, the AI-xQTL project
- April 14, Yifei and Xuewei, transBoost (II)
- April 21, Hao + Alex (and the lab), Nature Protocols manuscript updates & Alex + Yanghyeon’s update
- April 28, Ruixi, Multiome data for African brains and QTL analysis (II)
- May 5, No meeting, FunGen-xQTL symposium / FunGen-AD conference
| Date | Presenter | Research Topic | “Fundamental Reasoning in StatFunGen” |
|---|---|---|---|
| Jan 13 | All | Kick-off meeting | - |
| Jan 27 | Ru | SSU and SSU QTL (I) | “Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms” [Cell, 2019]; “A brief history of human disease genetics” [Nature, 2020] |
| Feb 3 | Yifei | transBoost (I) | “Trans Effects on Gene Expression Can Drive Omnigenic Inheritance” [Cell, 2019]; “Plasma proteomic associations with genetics and health in the UK Biobank” [Nature, 2023] |
| Feb 10 | Xuewei, Anjing, Haochen | Orthogonal data validation approaches | “Effective gene expression prediction from sequence by integrating long-range interactions” [Nature Methods, 2021]; “Widespread signatures of natural selection across human complex traits and functional genomic categories” [Nature Communications, 2021] |
| Feb 24 | Ruixi | Multiome data for African brains and QTL analysis (I) | “The role of regulatory variation in complex traits and disease” [NRG, 2015]; “Genetic and molecular architecture of complex traits” [Cell, 2024] |
| Mar 3 | Haochen, Alex | Fine-mapping methods project updates | “Dissecting the genetics of complex traits using summary association statistics” [NRG, 2017]; “A practical view of fine-mapping and gene prioritization in the post-genome-wide association era” [Open Biology, 2020] |
| Mar 10 | Ru, Gao | xQTL manuscript bundle status | Recent work on xQTL outside of the lab |
| Mar 17 | Anjing | multifSuSiE on multiome data | “Regulatory genomic circuitry of human disease loci by integrative epigenomics” [Nature, 2020]; “From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases” [Front Genet, 2020] |
| Mar 24 | Ru | SSU and SSU QTL (II) | The GTEx Consortium atlas of genetic regulatory effects across human tissues” [Science, 2020]; “Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries” [Nature Genetics, 2023] |
| Mar 31 | Chunming | AD TWAS updates | “On the problem of inflation in transcriptome-wide association studies” [bioRxiv, 2023]; “Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain” [Nature Genetics, 2023] |
| Apr 7 | Guest speakers | glycoQTL and AI-xQTL projects | - |
| Apr 14 | Xuewei (research update), Yifei (“fundamental reasoning”) | transBoost (II) | “A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine” [Trends in Genetics, 2020]; “Genetic associations of protein-coding variants in human disease” [Nature, 2022] |
| Apr 21 | Yanghyeon, Alex | Project updates: MR and susie-ash | “A robust and efficient method for Mendelian randomization with hundreds of genetic variants” [Nature Communications, 2019]; “Using genetic association data to guide drug discovery and development” [AJHG, 2023] |
| Apr 28 | Ruixi | Multiome data for African brains and QTL analysis (II) | Gao: remaining highlights from the statgen-papers list: LDSC and PRS overview. |
| May 5 | All | FunGen-xQTL symposium / FunGen-AD conference | - |